I have extensive experience with Wellbutrin/caffiene. I find both together, makes a caffiene crash worse. For me that means being in an odd mood/irritable, but for some that means tiredness. What's eHealthMe? eHealthMe is a health data analysis company based in Mountain View, California. eHealthMe monitors and analyzes the outcomes of drugs and supplements that are currently on the market. I have been taking Bupropion SR 150 mg. this is day three and I am so damn tired too. I am giving it a chance though. I'm off from work for a few weeks so I'm dealing with it. Do you know if there is more benifits as far as weight lost with the Wellbutrin SR then the Wellbutrin XL. Read More I have been on Wellbutrin XL 300 mg for the past 6 months. This is a reivew of how effective Wellbutrin (bupropion hydrochloride) is for Fatigue and for what kind of people. The study is created by eHealthMe from 25 Wellbutrin users and is updated continuously. Wellbutrin (bupropion) is a prescription antidepressant medication indicated for the treatment of depression and seasonal affective disorder. This medication is administered orally (tablet or extended-release tablet) and should be taken as prescribed by your doctor. While taking this medication, you can experience negative side effects from Wellbutrin, which should be discussed with your doctor. Uses: Wellbutrin SR is prescribed for Depression and is mostly mentioned together with this indication. In addition, our data suggest that it is taken for Anxiety and Tiredness, although it is not approved for these conditions*. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Namey on can wellbutrin cause fatigue: Effect. Less common, but can occur! Tom Wilson’s in-person hearing will be held Wednesday morning at the last update 2019/03/26 last update NHL’s New York office. Laurie, Thank you for the response! It's been a while since I've tried a new medication and I have heard good and bad things about Wellbutrin, but everyone is different and I'm hoping this is one that will do well for me.